Results
| PMID | 16136892 |
| Gene Name | THBS1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 63 |
| Population details | 63 (38 patients with endometriosis, 25 specimens of endometrium were biopsied from women without endometriosis) |
| Sex | Female |
| Associated genes | TSP-1, VEGF |
| Other associated phenotypes |
Endometriosis |
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Zhonghua Fu Chan Ke Za Zhi. 2001 Dec;36(12):727-30. Tan, X| Lang, J| Liu, D Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. OBJECTIVE: To detect the expression of vascular endothelial growth factor (VEGF) and thrombospondin (TSP)-1 mRNA in the ectopic and eutopic endometrium of patients with endometriosis. METHODS: Thirty-two specimens of ovarian endometrioma, 12 red peritoneal lesion, 8 uterosacral ligament nodule, and 30 matched eutopic endometrium were biopsied from 38 patients with endometriosis, another 25 specimens of endometrium were biopsied from women without endometriosis. Reverse transcript-polymerase chain reaction (RT-PCR) and Northern Blot analysis were utilized to examine VEGF mRNA and TSP-1 mRNA expression and their relative levels in the above endometrium. RESULTS: Among endometriotic lesions, red peritoneal lesion expressed higher level of VEGF and lower level of TSP-1, whereas ovarian endometrioma expressed lower level VEGF and higher level of TSP-1. Eutopic endometrium of women with endometriosis had higer level of VEGF expression and lower level of TSP-1 expression than women without endometriosis. CONCLUSIONS: The expression of VEGF and TSP-1 in endometriotic lesion appears to be associated with its neovalscualization extent. The imbalance in expression of VEGF and TSP-1 in endometrium might be related to the development of endometriosis and its biological behavior. Mesh Terms: Blotting, Northern| Endometriosis/*metabolism| Endometrium/*metabolism| Female| Humans| Ovarian Diseases/*metabolism| RNA, Messenger/metabolism| Reverse Transcriptase Polymerase Chain Reaction| Thrombospondin 1/genetics/*metabolism| Vascular Endo |
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